𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Asymmetric synthesis of the key intermediate of an SP antagonist RPR107880 using a base-catalyzed Diels–Alder reaction

✍ Scribed by Hiroaki Okamura; Hideki Shimizu; Yasuko Nakamura; Tetsuo Iwagawa; Munehiro Nakatani

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
116 KB
Volume
41
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

An asymmetric synthesis of the key intermediate of RPR 107880, a substance P antagonist, using a basecatalyzed Diels-Alder reaction of 3-hydroxy-2-pyrone and N-benzylmaleimide is described.

📜 SIMILAR VOLUMES

ChemInform Abstract: Asymmetric Synthesi
ChemInform Abstract: Asymmetric Synthesis of the Key Intermediate (VII) of an SP Antagonist RPR 107880 (VIII) Using a Base-Catalyzed Diels—Alder Reaction.
✍ Hiroaki Okamura; Hideki Shimizu; Yasuko Nakamura; Tetsuo Iwagawa; Munehiro Nakat 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Synthesis of (+)-epiepoformin using the
Synthesis of (+)-epiepoformin using the base-catalyzed Diels–Alder reaction of 3-hydroxy-2-pyrone
✍ Hideki Shimizu; Hiroaki Okamura; Naomi Yamashita; Tetsuo Iwagawa; Munehiro Nakat 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 72 KB

Asymmetric total synthesis of (+)-epiepoformin was achieved in short steps using the base-catalyzed asymmetric Diels-Alder (DA) reaction of 3-hydroxy-2-pyrone with chiral acrylate. Since the synthesis produced Ogasawara's intermediate, it is also presented as a formal synthesis of (-)-theobroxide.