Asymmetric Synthesis of the Four Possible Fagomine Isomers.
โ Scribed by Hiroki Takahata; Yasunori Banba; Hidekazu Ouchi; Hideo Nemoto; Atsushi Kato; Isao Adachi
- Book ID
- 101943816
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 63 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
## Tandem conjugate addition by an O-silylcyanohydrin derived carbanion to 5-(1-menthy10xy)-~5~~0~, followed by reaction with an ammatic aldehyde gives two dktereoisomfxic adducts. T&se. afford a single product on treatment with tcrrabutylammonium tluolide. Reduction with concomitant removal of t
The synthesis of all four individual isomers of 3-methyl-3-(2'-naphthyl)analine was accomplished using asymmetric conjugate 1 A-addition followed by direct or indirect azidation using an Evans-type chiral auxiliary (4-phenyl-2-oxazolidinone).