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Asymmetric synthesis of tetrahydroisoquinolines by enzymatic Pictet–Spengler reaction

✍ Scribed by Nishihachijo, Masakatsu; Hirai, Yoshinori; Kawano, Shigeru; Nishiyama, Akira; Minami, Hiromichi; Katayama, Takane; Yasohara, Yoshihiko; Sato, Fumihiko; Kumagai, Hidehiko


Book ID
127095928
Publisher
Japan Science and Technology Information Aggregator, Electronic
Year
2014
Tongue
English
Weight
716 KB
Volume
78
Category
Article
ISSN
0916-8451

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## Abstract magnified image New tetrahydroisoquinolines were synthesized by the Pictet‐Spengler reaction. Influence of a wide range of aryl and heteroaryl aldehydes, was investigated in the cyclization step with 3,4‐dimethoxyphenylethylamine **1**, L‐DOPA **2** and L‐3,4‐dimethoxyphenylalanine met