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Asymmetric synthesis of tetracyclic substructures of Strychnos indole alkaloids

✍ Scribed by Mercedes Amat; M.-Dolors Coll; Núria Llor; Carmen Escolano; Elies Molins; Carles Miravitlles; Joan Bosch

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
262 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

The addition of the enolate of methyl 1-methyl-2-indoleacetate 1 and lithium 2-(lithiomethyl)indole-1-carboxylate 5 to pyridines and N-alkylpyridinium salts bearing a chiral auxiliary at the 3-position (tolylsulfinyl, acyl iron complexes, bornane-10,2sultam), with subsequent acid cyclization of the resulting dihydropyridines, is investigated.

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