Intermediates for the synthesis of tetracyclic indole alkaloids. Synthesis of 4-aminotetrahydrocarbazole derivatives
✍ Scribed by Süleyman Patir; Görol Okay; Ahmet Gülce; Bekir Salih; Tuncer Hökelek
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1997
- Tongue
- English
- Weight
- 299 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
An efficient method for the synthesis of 4‐aminotetrahydrocarbazole derivatives from 2,3‐dihydrospiro‐[1__H__‐carbazole‐1,2′‐(1,3)‐dithiolan]‐4‐(9__H__)‐one 1 is described. The structure of compound 6 has been confirmed by X‐ray structure analysis.
📜 SIMILAR VOLUMES
## Abstract The synthesis of new precursors **8** and **15** for the synthesis of tetracyclic indole alkaloids were described. Many new intermediates **4‐7** and **9‐14** have also been synthesized.
## Abstract The synthesis of aldehyde intermediates suitable for the preparation of indole alkaloids of the tacamine (1) type is described. The four possible aldehydes 4–7 were prepared from methyl 5‐ethylnicotinate (8) in a few simple steps using a base‐catalyzed epimerization as the final step (_
## Abstract Key intermediates of type **2** serving the synthesis of reserpine‐type alkaloids were prepared in different routes.