𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Asymmetric synthesis of spirocyclic pyrrolidines and tetrahydrofurans by chiral aldol reactions and phenylthio migration

✍ Scribed by Kelly Chibale; Stuart Warren


Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
238 KB
Volume
32
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Stereochemically controlled synthesis of
✍ Iain Coldham; Eric W. Collington; Peter Hallett; Stuart Warren πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 French βš– 196 KB

Phenylthio migration coupled to stereoselective aldol reactions provides single diastereoisomers of allylic sulphides and spirocyclic tetrahydrofurans and butenolides based on the piperidine and quinuclidine skeletons.

Synthesis of (+)-discodermolide and anal
✍ Ian Paterson; Gordon J Florence πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 180 KB

The boron-mediated aldol reactions of the (Z)-enals 3 and 7 proceed with high levels of 1,4-stereoinduction arising from the g-substituent. Reagent control from (+)-Ipc 2 BCl can be used eectively to overturn this substrate bias, thus enabling the stereocontrolled formation of (+)-discodermolide (1)