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Asymmetric Synthesis of Salvinorin A (I), a Potent ϰ Opioid Receptor Agonist.

✍ Scribed by Jonathan R. Scheerer; Jonathan F. Lawrence; Grace C. Wang; David A. Evans


Publisher
John Wiley and Sons
Year
2007
Weight
14 KB
Volume
38
Category
Article
ISSN
0931-7597

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## Abstract 2‐(3,4‐Dichlorophenyl)‐N‐methyl‐N‐[(1S)‐1‐(3‐isothiocyanatophenyl)‐2‐(1‐pyrrolidinyl)ethyl]acetamide (1, DIPPA) has been previously reported to be an opioid receptor affinity label that produces selective and long‐lasting κ opioid receptor antagonism in mice, High specific activity [^3^