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Asymmetric synthesis of polyfunctionalized piperidines: substitution at the C-4 position

✍ Scribed by Florence Billon-Souquet; Thierry Martens; Jacques Royer

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 228 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00625-5

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✦ Synopsis

The electrochemical bis-bromination of the chiral building block 1 followed by a dehydrobromination step allowed the preparation of a bromopiperideine 3. The stereoselective addition of nucleophiles onto this key intermediate permitted the synthesis of various 4-substituted piperidine derivatives.

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