All the four individual isomers of R-methylphenylalanine have been synthesized in very high optical purities by utilizing in part the chiral imide enolate bromination methodology of Evans and co-workers. Substitution of the diastereotopic X-hydrogens of many a-amino acids provides inprinciple, an a
Asymmetric synthesis of optically pure β-isopropylphenylalanine: A new β-branched unusual amino acid
✍ Scribed by Subo Liao; Victor J. Hruby
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 206 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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We have developed methods for the synthesis of the four optically pure isomers of B-methyltryptophan with the 2-mesitylenesulfonyl indole protecting group for peptide synthesis. Starting from 3-indoleacrylic acid, the Bmethyl function was generated by a chiral auxiliary-directed asymmetric conjugate
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