Asymmetric synthesis of LY354740: A highly potent and selective group 2 mGluR agonist
✍ Scribed by Carmen Domínguez; Jesús Ezquerra; Modesta Espada; Carmen Pedregal; Lourdes Prieto
- Book ID
- 116037936
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 126 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0028-3908
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📜 SIMILAR VOLUMES
Efficient synthesis of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740: 1) and its structurally related analogs (-)-2 and (-)-3 has been accomplished starting with (1S,2R)-1-amino-2-hydroxycyclopentane-or cyclohexanecarboxylic acid (4 or 17 ) via an intramolecular cyclopropanation of
Compounds which affect glutamate transmission are reported as anxiolytic in a number of animal models. In the present studies, we evaluated the anxiolytic effect of a new mGluR2 agonist, LY354740, in rats and pigeons. LY354740 was evaluated in three different rat punished responding assays, using di