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Asymmetric synthesis of lactones with high enantioselectivity by intramolecular carbon-hydrogen insertion reactions of alkyl diazoacetates catalyzed by chiral rhodium(II) carboxamides

✍ Scribed by Doyle, Michael P.; Van Oeveren, Arjan; Westrum, Larry J.; Protopopova, Marina N.; Clayton, Thomas W.


Book ID
126172075
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
400 KB
Volume
113
Category
Article
ISSN
0002-7863

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Enantiocontrol and regiocontrol in lacta
✍ Michael P. Doyle; Marina N. Protopopova; William R. Winchester; Kirsten L. Danie πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 French βš– 243 KB

Dirhodium(ll) catalysts possessing chiral pyrrolidone or oxazolidinone ligands provide moderate enantioconfrol (up to 80% ee) in carbon-hydrogen insertion reactions of N-alkyl-N-(tert -butyl)diazoacetamides; substituents at the P-position of the N-alkyl group control regioselectivity for p-and ylact