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Asymmetric Synthesis of Hydroxyphosphonates

✍ Scribed by Oleg I. Kolodiazhnyi


Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract The reduction of dimenthyl ketophosphonates with sodium borohydride involves asymmetric induction at the α‐carbon atom, resulting in a small excess of the (R)‐enantiomer of the α‐hydroxyphosphonate formed. A higher ee purity was achieved if the reduction of chiral dimenthyl ketophosphon