Asymmetric Addition of Chiral 1,3,2-Benzoxazaphosphinine 2-Oxides to Aldehydes: Diastereoselective Synthesis of α-Substituted β-Hydroxyphosphonic Acids.
✍ Scribed by Beatriz Lopez; Alicia Maestro; Rafael Pedrosa
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 46 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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The chiral formylferrocenes 2-5 have been readily prepared in good yields by ortho-lithiation of the TMS-blocked orunblocked aminoferrocenes and subsequent reaction with DMF. The stereochemistry of the reaction of 2 with organometallic reagents has been examined. Reactions of 2 with Grignard and org