Asymmetric Synthesis of Highly Substituted γ-Amino Acids from Allyltitanium Sulfoximines
✍ Scribed by Köhler, Franz; Gais, Hans-Joachim; Raabe, Gerhard
- Book ID
- 127307886
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 103 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
A lacile slereoselcctive melhod Ior the synthesis of y-substituted, y-mnino acids from of amino acids was developed. The key step of the procedurc is complete reduction of Ihe keto functionality of ot-~unino acyl Meldruln's acid by sodium acetoxyborohydride. The resulting amino alkyl Meldrum's acid
Facile Stereoselective Synthesis of γ-Substituted γ-Amino Acids from the Corresponding α-Amino Acids. -The mild and short procedure presented is compatible with common side-chain protecting groups, sensitive functionalities and preserves the chirality of the starting α-amino acid.