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Asymmetric Synthesis of Functionalized Aza-Cyclic Amino Acids with Quaternary Stereocenters by a Phase-Transfer-Catalyzed Alkylation Strategy

โœ Scribed by Ooi, Takashi; Miki, Takashi; Maruoka, Keiji


Book ID
125893497
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
140 KB
Volume
7
Category
Article
ISSN
1523-7060

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Highly enantioselective synthesis of cyc
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The chiral quaternary ammonium salt 1 serves as phase transfer catalyst for the enantioselective conversion of the glycine derivative 2 to a variety of cyclic and acyclic chiral oramino acids with enantioselectivities as high as 200:1 in alkylation and Michael addition reactions.