Highly enantioselective synthesis of cyclic and functionalized α-amino acids by means of a chiral phase transfer catalyst

✍ Scribed by E.J Corey; Mark C Noe; Feng Xu

• Book ID: 104259548
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 247 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01067-3

✦ Synopsis

The chiral quaternary ammonium salt 1 serves as phase transfer catalyst for the enantioselective conversion of the glycine derivative 2 to a variety of cyclic and acyclic chiral oramino acids with enantioselectivities as high as 200:1 in alkylation and Michael addition reactions.