✦ LIBER ✦

Asymmetric synthesis of cyclopentylamine derivatives, intermediates for carbocyclic nucleoside synthesis. Carbocyclization of 2-amino-5-hexenyl radicals

✍ Scribed by José Marco-Contelles; Manuel Bernabé

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 254 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73433-2

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✦ Synopsis

Carbocyclicnuclcosidcs~~yLnpomntraoitllmalmbuwivinl2rccivitit&~ly,agnattffon~ bum &voted to the chirospecific syntbcaia of there co-3 Tile most cl4qpnt lnethod4 involves the tmnsfdon of u3alltiomcliuuy pum cyclopentylamhlc dWivativc$ iILt0 the WrqoWEng nIBckosides following the smmkxd mce~odologiu~xn this cooext, WC have m rbe efficient, utive ami enantiospscific~~saf~~~~~daivrtivesuby5au,~~cyclintianafpscmsas of type I (PO-0-protaAng group) prqmrcd fmm D-ribonokctonc' (Schemt 1). Now, in an altcmntive appmachwdcsrribcfo+~prst~thcpnporetion Gfchid ttmbocyhntane tkrhtba Iibyfiee mdical cycikani~nqf 2-mnino-s-hucnylrcrdicalstff,~in~anbeobbinedfrom~daivad ffomL-

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