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Asymmetric Synthesis of Cyclic cis -β-Amino Acid Derivatives Using Sulfinimines and Prochiral Weinreb Amide Enolates

✍ Scribed by Davis, Franklin A.; Theddu, Naresh


Book ID
118166698
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
1021 KB
Volume
75
Category
Article
ISSN
0022-3263

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The use of cis-aminoindanol as a chiral auxiliary for asymmetric synthesis of c~-amino acids is described. Alkylation of the chirally modified glycine enolate 2 with a number of alkyl halides in the presence of lithium chloride gave the corresponding alkylated product in 90 -99% diastereoselectivity