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Practical synthesis of α-amino acids using cis-aminoindanol derived hippuric acid amide as a glycine enolate equivalent

✍ Scribed by Jaemoon Lee; Woo-Baeg Choi; Joseph E Lynch; R.P Volante; P.J Reider

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 182 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00636-4

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✦ Synopsis

The use of cis-aminoindanol as a chiral auxiliary for asymmetric synthesis of c~-amino acids is described. Alkylation of the chirally modified glycine enolate 2 with a number of alkyl halides in the presence of lithium chloride gave the corresponding alkylated product in 90 -99% diastereoselectivity.

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