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Asymmetric synthesis of chiral β-hydroxy-α-amino acid derivatives by organocatalytic aldol reactions of isocyanoesters with β,γ-unsaturated α-ketoesters

✍ Scribed by Lin, Ning; Deng, Yan-Qiu; Zhang, Zhen-Wei; Wang, Qian; Lu, Gui


Book ID
121787992
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
968 KB
Volume
25
Category
Article
ISSN
0957-4166

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## Abstract An easily available and efficient chiral __N__,__N__′‐dioxide–nickel(II) complex catalyst has been developed for the direct catalytic asymmetric aldol reaction of α‐isothiocyanato imide with aldehydes which produces the products in morderate to high yields (up to 98 %) with excellent di