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Asymmetric Synthesis of Both Enantiomers of a δ-Lactone Analogue of Muricatacin

✍ Scribed by Doran, Robert; Guiry, Patrick


Book ID
121526945
Publisher
Thieme Medical Publishers
Year
2014
Tongue
German
Weight
216 KB
Volume
46
Category
Article
ISSN
0039-7881

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The asymmetric synthesis of both enantiomers of the racemic NMDA antagonist eliprodil was accom lished in a novel application of Shsrpless' asymmetric diiydroxylation (AD) methodology. A drf erence in neuroprotective activity was noted for the enantiomers in an in viva \*P model of rat focal cerebra