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Asymmetric Synthesis of Bicyclic Amidines via Rhodium-Catalyzed [2+2+2] Cycloaddition of Carbodiimides

✍ Scribed by Yu, Robert T.; Rovis, Tomislav


Book ID
126062758
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
83 KB
Volume
130
Category
Article
ISSN
0002-7863

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An efficient solid-phase synthesis of isoindolines is reported. The key reaction step is a rhodium-catalyzed [2+2+2] cycloaddition of alkynes to give isoindolines in good yield.