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Asymmetric synthesis of arylglycine amino acids using (S,S)-(+)-pseudoephedrine derived amides

✍ Scribed by Jose L. Vicario; Dolores Badía; Esther Domínguez; Ana Crespo; Luisa Carrillo; Eneritz Anakabe


Book ID
104262256
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
180 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis


Arylglycine aminoacids were obtained in good yields and with enantiomeric excesses higher than 99% by using an asymmetric amination reaction protocol on (S,S)-(+)-pseudoephedrine based arylacetamide enolates with di-tert-butylazodicarboxylate. Subsequent hydrazinolysis and hydrolysis yielded the target aminoacids.


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