A practical asymmetric synthesis of carn
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M. Kitamura; T. Ohkuma; H. Takaya; R. Noyori
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Article
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1988
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Elsevier Science
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French
โ 175 KB
The first efficient chemical synthesis of (I?)-carnitine has been accomplished on the basis of homogeneous enantioselective hydrogenation of ethyl 4-chloro-3oxobutanoate. We recently demonstrated that the BINAP-based Ru(I1) catalysts have remarkable