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A practical asymmetric synthesis of carnitine

✍ Scribed by M. Kitamura; T. Ohkuma; H. Takaya; R. Noyori

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 175 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)80350-0

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✦ Synopsis

The first efficient chemical synthesis of (I?)-carnitine has been accomplished on the basis of homogeneous enantioselective hydrogenation of ethyl 4-chloro-3oxobutanoate.

We recently demonstrated that the BINAP-based Ru(I1) catalysts have remarkable

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