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Asymmetric Synthesis of 5-(1-Hydroxyalkyl)tetrazoles by Catalytic Enantioselective Passerini-Type Reactions

✍ Scribed by Tao Yue; Mei-Xiang Wang; De-Xian Wang; Jieping Zhu

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 309 KB
Volume: 47
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200804213

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✦ Synopsis

Asymmetric Synthesis of 5-(1-Hydroxyalkyl)tetrazoles by Catalytic Enantioselective Passerini-Type Reactions** Scheme 1. Catalytic enantioselective synthesis of 5-(1-hydroxyalkyl)tetrazole 1 by three-component Passerini reaction (P-3CR).

Figure 1. Catalysts screened for enantioselective synthesis of 1-(4methoxyphenyl)-5-(1-hydroxyisobutyl)tetrazole 1 a by P-3CR. [

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Scheme 1. Catalytic enantioselective synthesis of 5-(1-hydroxyalkyl)tetrazole 1 by three-component Passerini reaction (P-3CR). Figure 1. Catalysts screened for enantioselective synthesis of

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