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Asymmetric synthesis of (3S,1′S)-3-(1-amino-2,2,2-trifluoroethyl)-1-(alkyl)-indolin-2-one derivatives by addition of (S)-N-t-butylsulfinyl-3,3,3-trifluoroacetaldimine to 1-(alkyl)-indolin-2-ones

✍ Scribed by Qian, Ping; Xie, Chen; Wu, Lingmin; Mei, Haibo; Soloshonok, Vadim A.; Han, Jianlin; Pan, Yi


Book ID
126507623
Publisher
Royal Society of Chemistry
Year
2014
Tongue
English
Weight
245 KB
Volume
12
Category
Article
ISSN
1477-0520

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Synthesis and CNS Activity of N,N-Disubs
✍ Rajesh Agarwal; Shobha Misra; Rajiv K. Satsangi; Shiva S. Tiwari 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 245 KB 👁 2 views

## Abstract Isatin and 5‐methylisatin were condensed with various aryloxyacetylhydrazides to furnish the 3‐(aryloxyacetylhydrazono)‐5‐alkylindolin‐2‐ones **1–4**. When **1–4** were subjected to __Mannich__ reaction, the __N,N__‐disubstituted 1‐(aminomethyl)‐5‐alkyl‐3‐(aryloxyacetylhydrazono)indolin