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Asymmetric synthesis of 2-substituted chroman-4-ones using lipase-catalyzed kinetic resolutions

โœ Scribed by Masashi Kawasaki; Hiroko Kakuda; Michimasa Goto; Shigeki Kawabata; Tadashi Kometani


Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
140 KB
Volume
14
Category
Article
ISSN
0957-4166

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๐Ÿ“œ SIMILAR VOLUMES


Approaches to 2-substituted chroman-4-on
โœ Kevin J Hodgetts ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 94 KB

Two approaches to optically active 2-substituted chroman-4-ones are described. The first utilized the oxidation of a preformed chroman ring and the second an intramolecular Mitsunobu cyclization. The methodology was applied to the synthesis of the biologically active natural product (-)-pinostrobin