Approaches to 2-substituted chroman-4-ones: synthesis of (−)-pinostrobin
✍ Scribed by Kevin J Hodgetts
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 94 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Two approaches to optically active 2-substituted chroman-4-ones are described. The first utilized the oxidation of a preformed chroman ring and the second an intramolecular Mitsunobu cyclization. The methodology was applied to the synthesis of the biologically active natural product (-)-pinostrobin (18).
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