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Approaches to 2-substituted chroman-4-ones: synthesis of (−)-pinostrobin

✍ Scribed by Kevin J Hodgetts


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
94 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis


Two approaches to optically active 2-substituted chroman-4-ones are described. The first utilized the oxidation of a preformed chroman ring and the second an intramolecular Mitsunobu cyclization. The methodology was applied to the synthesis of the biologically active natural product (-)-pinostrobin (18).


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