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Asymmetric Synthesis of 2-(2-Pyridyl)aziridines from 2-Pyridineimines Bearing Stereogenic N-Alkyl Substituents and Regioselective Opening the Aziridine Ring.

โœ Scribed by Diego Savoia; Giuseppe Alvaro; Romano Di Fabio; Andrea Gualandi; Claudio Fiorelli


Publisher
John Wiley and Sons
Year
2007
Weight
37 KB
Volume
38
Category
Article
ISSN
0931-7597

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Regioselective Nucleophilic Ring Opening Reactions of 2,2-Disubstituted Aziridines -The Asymmetric Synthesis of ฮฑ,ฮฑ-Disubstituted Amino Acids. -It is shown that, under appropriate conditions, 2,2disubstituted aziridines like (I) and (V) undergo regioselective ring opening reactions at C-3 with carb