Asymmetric Synthesis of 1,2,3-Trisubstituted Cyclopentanes and Cyclohexanes as Key Components of Substance P Antagonists.
β Scribed by Jeffrey T. Kuethe; Audrey Wong; Jimmy Wu; Ian W. Davies; Peter G. Dormer; Christopher J. Welch; Michael C. Hillier; David L. Huges; Paul J. Reider
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 174 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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## a b s t r a c t The reaction of 1-chlorovinyl p-tolyl sulfoxides, which were derived from ketones and chloromethyl p-tolyl sulfoxide, with lithium acetylides gave adducts in moderate to good yields. Treatment of the adducts with Grignard reagents resulted in the formation of magnesium carbenoids
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