✦ LIBER ✦

Asymmetric synthesis and absolute stereochemistry of cholesterol absorption inhibitor, SCH 48461

✍ Scribed by Duane A. Burnett

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 270 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/0040-4039(94)85308-8

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Metabolism and structure activity data b

Metabolism and structure activity data based drug design: discovery of (−) SCH 53079 an analog of the potent cholesterol absorption inhibitor (−) SCH 48461

✍ Syndeep Dugar; Nathan Yumibe; John W. Clader; Monica Vizziano; Keith Huie; Marga 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 180 KB

(−)-SCH 57939: synthesis and pharmacolog

(−)-SCH 57939: synthesis and pharmacological properties of a potent, metabolically stable cholesterol absorption inhibitor

✍ Michael P. Kirkup; Razia Rizvi; Bandarpalle B. Shankar; Sundeep Dugar; John W. C 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 250 KB

Gamma-lactams and related compounds as c

Gamma-lactams and related compounds as cholesterol absorption inhibitors: homologs of the beta-lactam cholesterol absorption inhibitor SCH 484611

✍ Sundeep Dugar; Michael P. Kirkup; John W. Clader; Sue-Ing Lin; Razia Rizvi; Mark 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 264 KB

Our search for potent cholesterol absorption inhibitors led to the discovery of the I~-lactam SCH 48461. Structure activity relationship studies prompted us to this study of y-lactams, ring homologs of 13lactam SCH 48461, to determine their potential as cholesterol absorption inhibitors. The results

ChemInform Abstract: Asymmetric Synthesi

ChemInform Abstract: Asymmetric Synthesis of Substituted 2-Azaspiro(3.5)nonan-1-ones: An Enantioselective Synthesis of the Cholesterol Absorption Inhibitor (+)- SCH 54016.

✍ L.-Y. CHEN; A. ZAKS; S. CHACKALAMANNIL; S. DUGAR 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Asymmetric synthesis and absolute stereo

Asymmetric synthesis and absolute stereochemistry of LY248686

✍ Jack Deeter; Jeff Frazier; Gilbert Staten; Mike Staszak; Leland Weigel 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 331 KB

Reduction of 3-(dialkylamino)-1-aryl-t-propanones with a 2:l complex of [(2R,3S-(+)-4--dimethylamino-1,2-diphenyl-3-methyl-2-butanol] (8) and lithium aluminum hydride (LAH) provided the corresponding 1,Saminoalcohols in high ee's (SO-88%). This process was developed and applied to the synthesis of L

Beta-lactams derived from the reaction o

Beta-lactams derived from the reaction of phenanthridines and 11H-dibenzo[b,e]azepin-11-one with phenylvaleryl chloride. Synthesis of fused analogs of the cholesterol absorption inhibitor Sch 48461

✍ Adriano Afonso; Stuart B Rosenblum; Mohindar S Puar; Andrew T McPhail 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 230 KB

Phenanthridines 4 and the l lH-dibenzo[b,e]azepin-I l-one 17 were used as the imine components in the ketene-imine ]3-1actam synthesis to provide the fused tetracyclic [3-1actams 7, 8 and 18.