**Asymmetrische Synthesen über heterocyclische Zwischenstufen, XXVI.– Asymmetrische Synthese eines Aminosäureesters mit einer 3,4‐Epoxyfunktion (β,γ‐Epoxyfunktion) nach der Bislactimether‐Methode** α‐Chlorketone **3** reagieren mit dem lithiierten Bislactimether **2** von __cyclo__(L‐Val‐Gly) zu de
✦ LIBER ✦
Asymmetric synthesesvia heterocyclic intermediates, XXXI. Asymmetric synthesis of various non-proteinogenic amino acid methyl esters (functionalized in the carbon chain) and amino acids by the bislactim ether method
✍ Scribed by Schöllkopf, Ulrich ;Busse, Ulrich ;Lonsky, Ralph ;Hinrichs, Rolf
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 866 KB
- Volume
- 1986
- Category
- Article
- ISSN
- 0947-3440
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The titanium derivative 4a of the bislactim ether l a from cyclo-(L-Val-Gly) reacts with + m a t u r a t e d aldehydes 5 exclusively by 1.2-addition in a highly diastereowlective mode to give virtually only the (2R,l'S) diastereomers of type 6. Upon hydrolysis these furnish the methyl (2R,3S)-thrm-2