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Asymmetric Strecker synthesis by addition of trimethylsilyl cyanide to aldehyde SAMP-hydrazones

✍ Scribed by Dieter Enders; Michael Moser


Book ID
108284752
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
93 KB
Volume
44
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


A New Asymmetric Synthesis of both Enant
✍ Enders, Dieter ;Tiebes, JΓΆrg πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 532 KB

## Abstract Both enantiomers of the hemlock alkaloid coniine 8 are prepared by asymmetric synthesis in 98% ee using only one enantiomer of the auxiliary. The key step of the synthesis consists in the 1,2‐addition of organoytterbium reagents to aldehyde SAMP hydrazones with virtually complete asymme