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Asymmetric Samarium-Reformatsky Reaction of Chiral α-Bromoacetyl-2-oxazolidinones with Aldehydes

✍ Scribed by Fukuzawa, Shin-ichi; Matsuzawa, Hiroshi; Yoshimitsu, Shin-ichi


Book ID
120890105
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
93 KB
Volume
65
Category
Article
ISSN
0022-3263

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Aldol reaction of N,N-dialkyl-a-isocyanoacetamides with primary alkyl aldehydes in the presence of 0.5-l mol% OF a chiral (aminoalkyl)ferrocenylphosphine-gold(I) catalyst proceeded with high enantio-and diastereoselectivity to give trans-5-alkyl-2-oxazoline-4-carboxamides of up to 98.6% ee, which we