Asymmetric reduction of prochiral ketones using polymer-supported catalysts and reagents

✍ Scribed by C. Caze

• Book ID: 103997786
• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 760 KB
• Volume: 26
• Category: Article
• ISSN: 1381-5148
• DOI: 10.1016/1381-5148(95)00058-n

✦ Synopsis

After a brief review of the literature on asymmetric reduction of prochiral ketones using polymer-supported catalysts or reagents some new results in this field are presented. In particular asymmetric reduction is reported here using (1) chiral oxazaborolidines as catalyst and BH3 as reducing agent, and (2) polymer reagents based on supported chiral amino alcohol and BHT.

The best enantiomeric excess obtained with these systems is 75%.