## Abstract A group of α‐ and β‐__N, N__‐dialkyl amino ketones were reduced enantioselectively by 2 moles of borane‐tetrahydrofuran in the presence of 10 mol% of the __in‐situ__ formed chiral oxazaborolidine, followed by diluted hydrochloric acid. The resulting amino alcohol‐borane complexes were t
Asymmetric Reduction of Ketoxime Derivatives and N-Alkylketimines with Borane—Oxazaborolidine Adducts.
✍ Scribed by Marek P. Krzeminski; Marek Zaidlewicz
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 195 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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Highly Enantioselective Reduction of Prochiral Ketones with N,N-Diethylaniline • borane (DEANB) in Oxazaborolidine-Catalyzed Reductions. -A variety of prochiral ketones (I) is enantioselectively reduced to the corresponding alcohols (II) using diethylaniline borane in the presence of a chiral oxazab
In the present work, quantum chemical computations of the enantioselective reduction of keto oxime ether with borane catalyzed by chiral oxazaborolidine are performed by means of the Hartree-Fock and the density functional methods. The structures of oxazaborolidine, oxazaborolidine-borane adduct, an