Asymmetric protected enoates as key intermediates towards an EPC synthesis of (+)-heptelidic acid
β Scribed by Gerhard Riehs; Ernst Urban
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 117 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogr
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