## Abstract In THF solution, NaBH~4~ in the presence of (__S__)‐(‐)‐1‐(2‐chlorophenyl)‐2,2‐dimethylpropane‐1,3‐diol together with 2‐chlorobenzoic acid reduced propiophenone to 1‐ phenylpropan‐1‐ol in up to 40% enantiomeric excess (__ee__). Only 21% __ee__ was obtained without an added acid. (__R__)
✦ LIBER ✦
Asymmetric organic reactions, IV. Asymmetric selection during a meerwein-ponndorf-verley type reaction in the presence of an optically active solvent
✍ Scribed by James D. Morrison; R.W. Ridgway
- Publisher
- Elsevier Science
- Year
- 1969
- Tongue
- French
- Weight
- 117 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Reaction of the bromomagnesium salt of racemic methylphenylcarbinol with acetophenone leads to an equilibration via MPV reduction.
-This equilibration is an invisible process in achiral solvent systems.
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Asymmetric Reduction and Meerwein-Ponndorf-Verley Reaction of Prochiral Aromatic Ketones in the Presence of Optically Pure 1-Aryl-2, 2-dimethylpropane-1,3-diols. -The title reactions are carried out in the presence of optically pure 1-aryl-2,2-dimethylpropane-1,3-diols, e.g. CPD and PDP, under vary