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Asymmetric organic reactions, IV. Asymmetric selection during a meerwein-ponndorf-verley type reaction in the presence of an optically active solvent

✍ Scribed by James D. Morrison; R.W. Ridgway


Publisher
Elsevier Science
Year
1969
Tongue
French
Weight
117 KB
Volume
10
Category
Article
ISSN
0040-4039

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✦ Synopsis


Reaction of the bromomagnesium salt of racemic methylphenylcarbinol with acetophenone leads to an equilibration via MPV reduction.

-This equilibration is an invisible process in achiral solvent systems.


📜 SIMILAR VOLUMES


Asymmetric reduction and Meerwein-Ponndo
✍ Hu Xianming; Richard M. Kellogg 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 736 KB

## Abstract In THF solution, NaBH~4~ in the presence of (__S__)‐(‐)‐1‐(2‐chlorophenyl)‐2,2‐dimethylpropane‐1,3‐diol together with 2‐chlorobenzoic acid reduced propiophenone to 1‐ phenylpropan‐1‐ol in up to 40% enantiomeric excess (__ee__). Only 21% __ee__ was obtained without an added acid. (__R__)

ChemInform Abstract: Asymmetric Reductio
✍ X. HU; R. M. KELLOGG 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Asymmetric Reduction and Meerwein-Ponndorf-Verley Reaction of Prochiral Aromatic Ketones in the Presence of Optically Pure 1-Aryl-2, 2-dimethylpropane-1,3-diols. -The title reactions are carried out in the presence of optically pure 1-aryl-2,2-dimethylpropane-1,3-diols, e.g. CPD and PDP, under vary