Diastereoselective alkylation of N-acylnorbornene sultams 2 afforded a variety of enantiomerically pure products 3a-3e. Reduction with LiAlH 4 (LAH) followed by ditosylation furnished chiral 1,4-ditosylates 5a-5e which underwent a cyclization reaction with primary amines to afford chiral 1,3-and 1,3
Asymmetric Multicomponent Reactions: Diastereoselective Synthesis of Substituted Pyrrolidines and Prolines.
β Scribed by Arun K. Ghosh; Sarang Kulkarni; Chun-Xiao Xu; Phillip E. Fanwick
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 37 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract New multicomponent reactions of aldehydes, isocyanides, trialkylboron reagents and dipolarophiles have been developed as an efficient route to diverse scaffolds, including aziridines, oxazolidines and polyβsubstituted pyrrolidines. This chemistry, inspired by a report by Hesse in 1965,
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