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Asymmetric Michael/cyclization tandem reaction of 4-hydroxycoumarin with β-nitroalkenes catalyzed by chiral bifunctional thioureas

✍ Scribed by Mei, Ren-Qiang; Xu, Xiao-Ying; Peng, Lin; Wang, Fan; Tian, Fang; Wang, Li-Xin


Book ID
120253727
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
159 KB
Volume
11
Category
Article
ISSN
1477-0520

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Highly asymmetric Michael additions of α
✍ Jian-Fei Bai; Xiao-Ying Xu; Qing-Chun Huang; Lin Peng; Li-Xin Wang 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 364 KB

A series of secondary amine-thiourea catalysts derived from L-proline and chiral diamine were prepared and first applied to the Michael addition of a,a-disubstituted aldehydes to trans-b-nitroalkenes. Moderate yields (47-75%) and excellent enantioselectivities (up to 96% ee) were obtained for a vari