Asymmetric Mannich Reactions of β-Keto Esters with Acyl Imines Catalyzed by Cinchona Alkaloids.
✍ Scribed by Sha Lou; Brandon M. Taoka; Amal Ting; Scott E. Schaus
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 34 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
## Abstract Asymmetric [4 + 2] cycloaddition of β,γ‐unsaturated α‐keto esters (I) and (IV) with oxazolones (II) proceeds with excellent diastereoselectivity and high enantioselectivity (up to 97% e.e.) in the presence of a quinidine‐derived bifunctional organocatalyst (NQD).
## Abstract Novel β‐amino esters bearing a bioactive benzothiazole moiety were obtained with high enantioselectivities (up to 95 % __ee__) through a Mannich‐type reaction of different imines with malonate in the presence of a new chiral cinchona alkaloid thiourea catalyst. Imines derived from both