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Asymmetric Hydrogenation of Pyridines: Enantioselective Synthesis of Nipecotic Acid Derivatives.

✍ Scribed by Aiwen Lei; Mao Chen; Minsheng He; Xumu Zhang


Publisher
John Wiley and Sons
Year
2007
Weight
29 KB
Volume
38
Category
Article
ISSN
0931-7597

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Enantioselective synthesis of Ξ±-aminopho
✍ Ute Schmidt; Hans Walter Krause; GΓΌnther Oehme; Manfred Michalik; Christine Fisc πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 208 KB πŸ‘ 1 views

Chiral ␣-aminophosphonic acid derivatives are efficiently synthesized by asymmetric hydrogenation of the prochiral N-acyl-␣,␀-dehydroaminophosphonates. PROPRAPHOS-Rh-catalysts from readily available (S)-and (R)-Propranolol proved to be suitable in the homogenous reaction affording an enantiomeric ex