Asymmetric hydrogenation of acetophenone catalyzed by cinchonidine stabilized Ir/SiO2

✍ Scribed by ChaoFen Yang; HeYan Jiang; Jian Feng; HaiYan Fu; RuiXiang Li; Hua Chen; XianJun Li

• Publisher: Elsevier Science
• Year: 2009
• Tongue: English
• Weight: 428 KB
• Volume: 300
• Category: Article
• ISSN: 1381-1169
• DOI: 10.1016/j.molcata.2008.10.041

✦ Synopsis

A series of silica (SiO 2 ) supported iridium catalysts stabilized by cinchona alkaloids was prepared and applied in the heterogeneous asymmetric hydrogenation of acetophenone. Cinchona alkaloids exhibited a marked ability to stabilize and disperse the Ir particles. In the presence of (1S,2S)diphenylethylenediamine ((1S,2S)-DPEN)) as chiral modifier, the cinchonidine (CD) stabilized catalyst 5%Ir/2CD-SiO 2 exhibited excellent catalytic performance in the asymmetric hydrogenation of acetophenone in MeOH. Under the optimum conditions, the ee value of (R)-phenylethanol achieved 79.8% and no other product was produced, a higher enantioselectivity than that reported up to now for acetophenone hydrogenation catalyzed by the supported metal catalysts modified by chiral reagents. In particular, a synergistic effect between (1S,2S)-DPEN and CD was observed, which significantly accelerated the reaction rate and enhanced the enantioselectivity. The catalyst can be reused several times without a significant loss of activity and enantioselectivity.