Asymmetric Hydroboration of 1,1-Disubstituted Alkenes

✍ Scribed by Stephen P. Thomas; Varinder K. Aggarwal

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 262 KB
• Volume: 48
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200805604

✦ Synopsis

Abstract

A breakthrough in the asymmetric hydroboration of notoriously difficult 1,1‐disubstituted alkenes using a new family of highly effective hydroboration reagents is described (see scheme). The intermediate boranes can be oxidized to alcohols or used in Suzuki–Miyaura cross‐coupling reactions.magnified image