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Asymmetric dihydroxylation in an approach to the enantioselective synthesis of 2-arylpropanoic acid non-steroidal anti-inflammatory drugs

✍ Scribed by Robert C. Griesbach; David P.G. Hamon; Rebecca J. Kennedy


Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
190 KB
Volume
8
Category
Article
ISSN
0957-4166

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A modification of the asymmetric dihydro
✍ Hiroyuki Ishibashi; Momoe Maeki; Junko Yagi; Masashi Ohba; Tae Kanai 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 344 KB

Catalytic hydrogenolysis of (S)-2-phenyl-l,2-pmpanediol (2), prepared by an asymmetric dihydroxylation of ot-methylstyrene (1) with AD-mix-ot, over Pcadman's catalyst gave (S)-2-phenyi-lpropanol (3). This method was applied to the synthesis of optically active 2-arylpropanoic acid antiinflammatory a