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A modification of the asymmetric dihydroxylation approach to the synthesis of (S)-2-arylpropanoic acids

✍ Scribed by Hiroyuki Ishibashi; Momoe Maeki; Junko Yagi; Masashi Ohba; Tae Kanai

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 344 KB
Volume: 55
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00279-3

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✦ Synopsis

Catalytic hydrogenolysis of (S)-2-phenyl-l,2-pmpanediol (2), prepared by an asymmetric dihydroxylation of ot-methylstyrene (1) with AD-mix-ot, over Pcadman's catalyst gave (S)-2-phenyi-lpropanol (3). This method was applied to the synthesis of optically active 2-arylpropanoic acid antiinflammatory agents, (S)-ibuprofen ( ) and (S)-naproxcn (13).

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