Asymmetric Desymmetrization of a σ-Symmetric Erythritol Derivative Using C2-Symmetric Bis-sulfoxide: a Total Synthesis of (+)-Aspicilin

✍ Scribed by Naoyoshi Maezaki; Ying-Xia Li; Kazumi Ohkubo; Satomi Goda; Chuzo Iwata; Tetsuaki Tanaka

• Book ID: 104202728
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 185 KB
• Volume: 56
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(00)00337-9

✦ Synopsis

AbstractÐA total synthesis of (1)-aspicilin 1 was accomplished via an asymmetric desymmetrization of a meso-erythritol derivative using a C 2 -symmetric bis-sulfoxide and a chelation-controlled Grignard reaction as the key steps.