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Asymmetric deprotonation of N,N-dihexyl-1-naphthamides to provide atropisomers of N,N-dihexyl-2-alkyl-1-naphthamides

โœ Scribed by S. Thayumanavan; Peter Beak; Dennis P. Curran


Book ID
103411370
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
225 KB
Volume
37
Category
Article
ISSN
0040-4039

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Atroposelective olefination of axially chiral N,N-dialkyl 2-formyl-1-naphthamides with chiral ligand-derived stable arsonium ylides proceeded in a kinetic resolution manner. The (E)-olefin products were obtained in excellent chemical yields and in up to 88:12 diastereoselectivity. Effects of the ami