Asymmetric cross-coupling reaction of sec-alkyl grignard reagents with organic halides in the presence of a chiral phosphine-nickel complex as a catalyst
β Scribed by Yoshihisa Kiso; Kohei Tamao; Norio Miyake; Keiji Yamamoto; Makoto Kumada
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- French
- Weight
- 233 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Swmnary: Dichloro[l,l~-bis(diphenylphosphino)ferrocene]palladium(II) was found to be an effective catalyst for the cross-coupling reaction of see-butylmagnesium chloride with bromobenzene, B-bromostyrene, and Z-bromopropene to give the corresponding see-butyl derivatives in exceedingly high yields.
The sequential coupling reactions of Grignard reagents with S-phenyl carbonochloridothioate in the presence of nickel(I1) or' iron(II1) catalysts provides a very mild and straightforward route to symmetrical and unsymmetrical aliphatic and aromatic ketones.